The Journal of Advances in Applied & Computational Mathematics is proud to announce the publication of a special issue on "AI and Metaheuristic Optimization Methods in Engineering and Biomedical Application". This special issue, guest edited by Dr. Juan Gabriel Aviña Cervantes, showcases seven articles that focus on the use of metaheuristic optimization algorithms to solve complex non-linear systems in engineering and biomedical applications. The articles demonstrate the reliability and effectiveness of these optimization techniques in solving problems where classical optimization techniques fail due to the complexity of the systems. The special issue aims to promote the practical and theoretical application of metaheuristic optimization techniques to solve engineering and science problems, with a focus on biomedical applications.